w7_Biomolecules

w7_Biomolecules - Morphology, Adhesion, Friction and Wear...

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NLIM NLIM OHIO STATE UNIVERSITY Morphology, Adhesion, Friction and Wear Properties of Biomolecules for BioMEMS/NEMS Dr. Dharma R. Tokachichu Prof. Bharat Bhushan NLIM Prof. Stephen C. Lee Matthew Keener Heart and Lung Research Institute Nanotribology Laboratory for Information Storage and MEMS/NEMS bhushan.2@osu.edu
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NLIM NLIM OHIO STATE UNIVERSITY Outline Background Various types of biosensors Points of friction and wear Surface modified by SAMs to reduce bioadhesion of polymers Objectives Experimenta l Sample preparation nanopatterning and chemical linker method AFM fluid cell Morphology, Adhesion, Friction and Wear of Biomolecules on Si-based Surfaces Morphological changes as a function of duration of buffer treatment physisorbed STA as a function of solution concentration with nanopatterning and chemical linker method Adhesion measurements various surfaces in PBS solution effect of pH of PBS solution Coefficient of friction of various surfaces Wear property of various surfaces SAMs to reduce bioadhesion of polymers Contact angle measurements Adhesion of uncoated and SAM coated PMMA and PDMS
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NLIM NLIM OHIO STATE UNIVERSITY The gate metal in MOSFET is replaced by a layer of receptor biomolecules. Works based upon the stimulus produced by biomolecular interactions. BioFET sensor Cantilever type biosensor Coated with a specific biomolecule or bacteria Works based upon the shift in the natural frequency of the cantilever and kinetics of the system. Background • Biomolecules, such as proteins, on silicon based surfaces are of importance in various bioMEMS application including silicon microimplants and biosensors Various types of biosensors
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NLIM NLIM OHIO STATE UNIVERSITY • The implanted bioMEMS such as sensors and drug delivery devices experience relative motion which causes friction and wear between the biomolecules and tissues resulting in degradation of the biomolecular function. Points of friction and wear
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NLIM NLIM OHIO STATE UNIVERSITY • In biosensors, the adhesion between the immobilized biomolecule and bioMEMS surface is a key factor which govern its performance and reliability. For implanted devices, friction and wear issues as well as biofouling need to be addressed. • The adhesion, friction and wear are scale dependent. Study of these properties need to be carried out at nanoscale.
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NLIM OHIO STATE UNIVERSITY Surface modification by SAM to reduce bioadhesion of polymers Polymers in BioMEMS To facilitate biofluid flow through nanochannels, surfaces with low bioadhesion are required. SAM coated surfaces are expected to provide low adhesion
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This note was uploaded on 07/17/2008 for the course CHEM 694 taught by Professor Dr.coe during the Spring '05 term at Ohio State.

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w7_Biomolecules - Morphology, Adhesion, Friction and Wear...

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