Biol 130 Unit 10 Notes - Biol 130 Unit 10 Notes...

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Biol 130 Unit 10 Notes: cytoskeleton Cytoskeleton A network of fibres forming ‘scafolding’ within cytoplasm Why is it important? Determines cell shape, position of organelles Allows movement of organelles/components within cells o Coordinates movement of chromosomes during mitosis Allows movement of cells themselves ‘motility’ o Forms flagella, cilia, lamellipodia Unlike our skeletons… Cytoskeleton is dynamic constantly being reorganized o Serves as both ‘bones’ and ‘muscles’ of the cell Do prokaryotes have cytoskeletons? Once thought to be a feature of eukaryotes only However o Recent advances in microscopy have shown that analogs of all the major cytoskeletal elements exist in prokaryotes Play similar roles as in eukaryotes Cell shape Cell division Cell polarity Model system for units 10, 11
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Cross section of intestinal mucosa Types of cytoskeletal filaments Microtubules- thickest, stiffest Intermediate- string like fibers that give the cell strength Microfilaments- thinnest, like string Intermediate filaments Microtubules intermediate filaments microfilaments
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Structural provide mechanical strength Form a network through cytoplasm of most animal cells, extending out to the cell periphery o Often anchored on plasma membrane at cell-cell junctions called desmosomes Intermediate filaments consist of long, twisted strands Structure of intermediate filaments Strands consist of long fibrous proteins, each with globular C-terminal tail and alpha- helical rod domain
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