733Lecture01

733Lecture01 - MOLECULAR GENETICS 733 HUMAN GENETICS...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
MOLECULAR GENETICS 733 HUMAN GENETICS ANALYSIS OF PATTERNS OF TRANSMISSION ( Paul Fuerst ) METHODS OF MOLECULAR PATHOLOGY AND DIAGNOSIS ( Tom Prior ) METHODS OF MOLECULAR ANALYSIS ( Arthur Burghes ) TEXTBOOK T. STRACHAN & A.P. READ HUMAN MOLECULAR GENETICS 3rd edition - 2004 READINGS - PATTERNS OF INHERITANCE Chapter 2; p. 43-49 chapter 3; all chapter 6; p 125-127 chapter 7; all chapter 10: 259 chapter 11; all chapter 12; all chapter 13; all chapter 15; 356-366 chapter 17; 415-425 chapter 19; all Course notes Course notes for Paul Fuerst can be accessed at: http://www.biosci.ohiostate.edu/~pfuerst/courses/index.html HUMAN INHERITANCE All human phenotypic characters require the interaction of many loci Possible modes of inheritance: Mendelian inheritance Polygenic (Quantitative) inheritance HUMAN INHERITANCE Mendelian inheritance Particular genotype at one locus is both necessary and sufficient for the character to be expressed
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
TERMS: Location Of Genes = Locus Different loci responsible for expression of different characters TERMS: ALLELES - alternative forms or states of a coding sequence of a locus example: ABO BLOOD GROUP alleles A1 A2 B O example: HEMOGLOBIN β LOCUS alleles: A, S, C, E, D, . ......... OMIM lists > 550 example: CYSTIC FIBROSIS alleles: many rare variants OMIM lists 130 “selected examples”
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 07/17/2008 for the course EEOB 733 taught by Professor Burghes during the Spring '05 term at Ohio State.

Page1 / 6

733Lecture01 - MOLECULAR GENETICS 733 HUMAN GENETICS...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online