733Lecture02extraslides

733Lecture02extraslides - LCR sequences in facilitating...

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1 FORMS OF GENETIC DISORDERS • 1. Chromosomal disorders – Types (ii): change in chromosome structure • Associated with LCR sequences – LCR = Low copy repeat sequence • LCV or CNP – LCV = Large scale copy number variation – CNP = Copy Number Polymorphism FORMS OF GENETIC DISORDERS • 1. Chromosomal disorders – Types (ii): change in chromosome structure • Recent information implicates
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Unformatted text preview: LCR sequences in facilitating duplications, deletions, inversions, translocations Mechanism = non-homologous recombination Other repeat sequences also implicated Alu FORMS OF GENETIC DISORDERS 1. Chromosomal disorders Types (ii): change in chromosome structure MICRODELETIONS New approaches: Comparative genomic hybridization (CGH)...
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This note was uploaded on 07/17/2008 for the course EEOB 733 taught by Professor Burghes during the Spring '05 term at Ohio State.

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