640Lecture0405extraslides

640Lecture0405extraslides - be specified for any number of...

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1 Human Genetic Load • How many “lethal equivalents” occur in the human genome? – Loci with alleles in heterozygous condition that if made homozygous would be lethal – Estimates vary between about 1.1 – 11 per genome Best estimates in range ~ 2.2 – 5.7 haplotype • the set of genes at more than one locus which is inherited by an individual from one of its parents. – A haplotype can
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Unformatted text preview: be specified for any number of loci. The frequency of a haplotype in a population can be counted as the number of gametes bearing a particular combination of genes. primates Within species polymorphisms: Orangutan Squirrel monkey Humans Chromosome 17 (MAPT haplotypes) H1 (common) and H2 (European) What about vertebrate or primate chromosomal polymorphism?...
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