g640Lecture13

G640Lecture13 - statistics of genetic variation allozymes statistics of genetic variation polymorphism proportion of polymorphic loci

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1 statistics of genetic variation statistics of genetic variation: allozymes • polymorphism – proportion of polymorphic loci • heterozygosity –observed – expected = 1 - Σ p i 2 = Σ2 p i p j • nucleotide polymorphism : θ – proportion of nucleotides expected to be polymorphic in a sample of size n • nucleotide diversity : π – average proportion of nucleotide differences between all possible pairs of sequences in the sample statistics of genetic variation: nucleotides i = 1 • nucleotide polymorphism : θ – proportion of nucleotides expected to be polymorphic in a sample of size n θ = S / a 1 – S = proportion of nucleotides polymorphic in the entire sample –a 1 = Σ 1 / i n-1 statistics of genetic variation: nucleotides nucleotide variation in a portion (2379 bp) of the Drosophila ADH gene 43 p 6 nucleotide polymorphism : θ θ = S / a 1 – S = proportion of nucleotides polymorphic in the entire sample • S = 43 / 2379 = 0.0181 n = 11 sequences 1 = Σ 1 / i = 1/1 + 1/2 + …. + 1/10 = 2.929 θ = S / a 1 = 0.0158 / 2.929 = 0.0062 n-1 i = 1
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This note was uploaded on 07/17/2008 for the course EEOB 640 taught by Professor Fuerst during the Spring '05 term at Ohio State.

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G640Lecture13 - statistics of genetic variation allozymes statistics of genetic variation polymorphism proportion of polymorphic loci

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