mutation - what are the forces which generate variation...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
1 1 what are the forces which generate variation mutation recombination migration 2 mutation 4 MUTATION original model - two allele forward mutation only WILD TYPE ----> MUTANT TYPE 5 MUTATION original model - two allele FORWARD MUTATION RATE = μ 6 MUTATION original model - two allele p 1 = p 0 (1- μ29 p 2 = p 1 (1- μ29 2 p t = p 0 (1- μ29 t
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 8 Assume p 0 ~ 1, then p t ~ p 0 -t μ Or, q t = q 0 + t μ Linear increase 10 How long does the process of increase of new mutations take? 11 MUTATION half life of a mutation: the time to get 1/2 the way to the equilibrium allele frequency from any starting point: t 1/2 = ln (0.5) / ln (1 - μ ) ~ 0.6931 / μ For one directional mutation, the equilibrium point is where the new mutation takes over the population (p = ~ 0) 12 MUTATION reversible mutation - two allele forward <-----> backward mutation WILD TYPE <----> MUTANT TYPE
Background image of page 2
3 13 MUTATION reversible mutation - two allele forward mutation rate = μ backward mutation rate = ν 14 MUTATION reversible
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 07/17/2008 for the course EEOB 640 taught by Professor Fuerst during the Spring '05 term at Ohio State.

Page1 / 7

mutation - what are the forces which generate variation...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online