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mutation

# mutation - what are the forces which generate variation...

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1 1 what are the forces which generate variation mutation recombination migration 2 mutation 4 MUTATION original model - two allele forward mutation only WILD TYPE ----> MUTANT TYPE 5 MUTATION original model - two allele FORWARD MUTATION RATE = μ 6 MUTATION original model - two allele p 1 = p 0 (1- μ 29 p 2 = p 1 (1- μ 29 2 p t = p 0 (1- μ 29 t

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2 8 Assume p 0 ~ 1, then p t ~ p 0 - t μ Or, q t = q 0 + t μ Linear increase 10 How long does the process of increase of new mutations take? 11 MUTATION half life of a mutation: the time to get 1/2 the way to the equilibrium allele frequency from any starting point: t 1/2 = ln (0.5) / ln (1 - μ ) ~ 0.6931 / μ For one directional mutation, the equilibrium point is where the new mutation takes over the population (p = ~ 0) 12 MUTATION reversible mutation - two allele forward <-----> backward mutation WILD TYPE <----> MUTANT TYPE
3 13 MUTATION reversible mutation - two allele forward mutation rate = μ backward mutation rate = ν 14 MUTATION reversible mutation - two allele

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mutation - what are the forces which generate variation...

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