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Unformatted text preview: dogs. Loewi (1921)- won nobel prize with frog heart experiment Sanger (1953)- won nobel prize for sequencing insulin DuVigneaud (1940s and 50s) prize for first lab synthesi s of peptide hormones Sutherland (1971)- cAMP and the enzyme responsible for its production, adenyl cyclase. cAMP, a secondary messenger: when cAMP levels are high, other enzymes are activated, leading to new biochemical reactions and a changed physiology. Harris (1955)- showed pituitary gland (which controlled activity of the entire endocrine system) was itself controlled. The hypothalamus of the brain was found to secrete neuropeptides which moved down to the pituitary. Yarrow (1978)- won nobel prize for developing radioimmunoassay (RIA) which enabled detection of hormones in blood or tissues. This was critical to isolation and study of hypothalamic hormones. Levi-Montalcini (1986)- won nobel prize for work with chemicals which control growth and differentiation....
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- Spring '08