Endocrinology study guide

Endocrinology study guide - dogs. Loewi (1921)- won nobel...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Endocrinology study guide Hormones : substances secreted by cells of ductless glands (endocrine glands) and some other tissues which leave their cell of origin, enter the extracellular space and diffuse to affect the physiology/ chemistry of other cells nearby, or more classically enter the circulatory system to affect more distance cells. Endocrinology: is the science concerned with hormone chemistry, source, synthesis, control of secretion and storage, mechanism of action and pathophysiology. Homeostasis: maintenance of the “steady state” Berthold- first endocrinological experiment 1849: castrated cockerels Bayliss and Starling (1902)- first to show existence of a hormone, considered the fathers of endocrinology. Vonmering and Minkowski (1889)- showed removal (ablation) of a dog’s pancreas caused diabetes mellitus symptoms. Banting and Best (1922)- went on to show that extracts of a particular type of tissue from the pancrease (islet cells) produced a compensatory drop in blood sugar in such diabetic
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: dogs. Loewi (1921)- won nobel prize with frog heart experiment Sanger (1953)- won nobel prize for sequencing insulin DuVigneaud (1940s and 50s) prize for first lab synthesi s of peptide hormones Sutherland (1971)- cAMP and the enzyme responsible for its production, adenyl cyclase. cAMP, a secondary messenger: when cAMP levels are high, other enzymes are activated, leading to new biochemical reactions and a changed physiology. Harris (1955)- showed pituitary gland (which controlled activity of the entire endocrine system) was itself controlled. The hypothalamus of the brain was found to secrete neuropeptides which moved down to the pituitary. Yarrow (1978)- won nobel prize for developing radioimmunoassay (RIA) which enabled detection of hormones in blood or tissues. This was critical to isolation and study of hypothalamic hormones. Levi-Montalcini (1986)- won nobel prize for work with chemicals which control growth and differentiation....
View Full Document

Ask a homework question - tutors are online