Lecture 9 10

Lecture 9 10 - Lecture 9 10/18/07 Endoplasmic Reticulum...

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Lecture 9 10/18/07 Endoplasmic Reticulum Trafficking For Multiple Transmembrane Proteins, contains start transfer sequences, with signal sequence Start Transfer There are 2 kinds: 1.) Signal sequence N-terminus, primary amino acid sequence Target protein for ER via SRP molecule Cleaved via signal peptidase Hydrophobic 8-15 amino acids long 2.) Start Transfer Sequence (C N inserted into ER mb) Anywhere in primary amino acid sequence (not just at N-term) Target protein for ER via SRP molecule Inserted into ER membrane (transmembrane domain) Hydrophobic also: 15-30 amino acids Not cleaved Proteins made as transmembrane proteins in ER have same orientation Stop Transfer Sequence N C Found anywhere in protein Part of already targeted protein with signal sequence or start transfer sequence Inserted into ER (transmembrane domain) Hydrophobic amino acids 15-30 long
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Translation at ER - Primary amino acid sequence aid in proteins, but it doesn’t mean they are
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This note was uploaded on 07/21/2008 for the course BICD 110 taught by Professor Mel during the Fall '06 term at UCSD.

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Lecture 9 10 - Lecture 9 10/18/07 Endoplasmic Reticulum...

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