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Lecture 16.5doc

Lecture 16.5doc - Lecture 16.5 Clarifications of Actin and...

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Lecture 16.5 11/16/07 Clarifications of Actin and Filaments/Critical Concentration Actin and filaments 2 main forms: o Free actin = monomers o G-Actin = globular (in book) o Free monomers come together F-actin, or filamentous actin Actins – monomers and filaments have polarity o (+) (-) end polarity o Barbed (+) vs. Pointed (-) how filament looks like under microscope o ATP at (+) end, more likely to stick to each other o ADP at (-) end, less likely to stick to each other o Addition of monomers at (+) end has a higher affinity for acquiring monomers in ATP form, bind more tightly to each other. After monomers incorporate into filament, ATP ADP hydrolysis, which makes filament more likely to depolymerize, considering state of ADP monomers less likely to stick to each other. o ATP cap causes a higher affinity, keeps filament from falling apart, after the hydrolyze to ADP depolymerization Critical Concentration Treadmilling – net loss of monomers from (-) end and net gain of monomers to (+) end o
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