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Unformatted text preview: Lecture 17 11/19/07 – Cytoskeleton: Actin continued and Myosin Toxins produced by plants, fungi, sponges target filament polymerization and act as defense against predation. • Provides protection for those that can’t get up and move away • These toxins affect actin cytoskeleton • Toxins are used in cell biology labs to help study cytoskeleton Proteins produced that affect cytoskeleton 1.) Cytochalasin – made by fungi, makes a cap at (+) end -promotes depolymerization at (-) end 2.) Phalloidin – made by fungi: deathcap mushroom-causes stabilization of filament, absolutely no depolymerization, continue to make actin filament but none will be destabilized-does this by inhibiting ATP hydrolysis-very toxic, if you ingest you will die 3.) Latrunculin – made by sea sponge-binds actin monomers and prevents polymerization-increases depolymerization 4.) Swinholide – sea sponge-severs actin filaments-sequesters actin dimers-acts similarly to latrunculin Organisms that use cytoskeleton to their advantage...
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