Lecture 22 12

Lecture 22 12 - Lecture 22 12/05/07 Programmed Cell Death...

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Lecture 22 12/05/07 Programmed Cell Death Programmed Cell Death – aka Apoptosis Purposes: o Problem in cell cycle (when cell fails to pass a checkpoint) o Whole organism homeostasis – balance out cell division so organism doesn’t lose or gain tissue o Part of developmental scheme o Basically: remove superfluous cells, damaged cells, or infected cells Contrast to Necrosis non-planned cell death o Cell ruptures, spill contents out inflammatory response Apoptosis vs. Necrosis o Apoptosis cell shrinks, phagocytosed by macrophages or another cell within organism, prevent proteases/other things from getting into extracellular matrix o Necrosis cell ruptures, cause inflammatory response that is negative Apoptosis is important for development in organism digits: o Get rid of what we don’t need o Tadpoles – need to lose tail when they mature to frog Apoptosis! Balancing out cell division: Adult tissue has a large amount of cell division need a large amount of programmed cell death to compensate
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Lecture 22 12 - Lecture 22 12/05/07 Programmed Cell Death...

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