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Unformatted text preview: + and K + channels) • AP travels both ways because of NMJ 2.) Transverse tubules – T-tubules spread AP to sarcomeres • Extension of sarcolemma down to sarcomeres, right along z-lines in humans • AP must get to sarcomeres at the same time C.) Ca ++ storage/release • Sarcoplasmic Reticulum (SR) RyR – 1 ryanodine receptor (SR Ca ++ channel) DHPR dihydropyridine receptor (L-type Ca ++ channel in T-tubule membrane) o Voltage gated channel, amount of Ca++ coming in is not important for triggering contraction. What is important is when depolarization hits this voltage gated receptor; it goes through a conformational change. Changes conformation of associated proteins Associated proteins – connect changes in voltage gated channel to changing the state of opening up RyR...
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This note was uploaded on 07/21/2008 for the course BIPN 105 taught by Professor Armour during the Winter '08 term at UCSD.
- Winter '08