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Lecture 3 Basis

# Lecture 3 Basis - Lecture 3 Basis/Propagation of the Action...

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Lecture 3 Basis/Propagation of the Action Potential Neurophysiology I. Neuron Anatomy In lab, we will look at axons, look at ability of axons to fire and transmit AP’s II. Neurons can maintain Membrane potential (V m ) Inside Outside [K + ] = 150 mM [K + ] = 5.5 mM [Na + ]= 15 mM [Na + ]= 150 mM Numbers change from neuron to neuron Generally: [K + ] is high on inside, [Na + ] is high on outside Equilibrium between concentration gradient going one way, electrical gradient going the other way Nernst Equation – calculate what membrane potential you need to have equilibrium balance between chemical and electrical potential Equilibrium potential (E ion ) = (1/z) 61 log [ion] out /[ion] in z = charge T = 37˚C E K+ = 1/+1 61 log [5.5]/[150] = -90 mV Equilibrium potential: inside of cell is negative, K + follow concentration gradient out, pull K + back in again Goldman Equation – because in real cell, there is no equal equilibrium potential. There are actually multiple ions crossing at same time, different permeabilities in

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Lecture 3 Basis - Lecture 3 Basis/Propagation of the Action...

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