REVISED6-03-08Notes - Lecture #19 Tuesday, 6/3/08 -1-...

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- 1 - Announcements: - Finals Week . Even though the US Open is being held at Torrey Pines during finals week, the university won’t allow “traffic delays” as legitimate excuses for being late to finals. In other words, you’ve been forewarned. - Old tests . Old tests on Webct are there to give you an idea of how the final test will be. Materials pertaining to the class not from Webct aren’t reliable sources of practice for our final. If you use them, do so with caution. You will only be tested on topics covered our lectures, the book is there to help clarify. - Rickets Disease and Skin cancer. The relationship between these two ideas was presented in lecture #16 (5/22/08). Proposed idea: Think of skin color as an abstract tug of war between lack of melanin (meaning less protection from UV mediated DNA damage and ultimately cancer) and too much melanin (preventing sunlight absorption, leading to inadequate amounts of vitamin D and ultimately inadequate calcium levels in the bones). - Tumor Stem Cells . It’s clear from experimental evidence that in tumor histological snapshots (of a particular timepoint during tumor development), there is a small subfraction of tumor cells capable to forming new tumors. In other words, even though all cells in the tumor are malignant, not all will grow to form new tumors. - In the news this week . You might notice a wave of cancer studies and results in the media as this week is the annual meeting of American Society of Clinical Oncology (ASCO). For example, physicians and companies will be announcing break through drugs in clinical trials, etc. - New York Times Article - With a Tiny Bit of Cancer, Debate on How to Proceed (6/3/08) The article will be put on Webct. The article discusses the conflict currently conferred onto patients and doctors regarding the relation of micrometastatic presence and the likelihood of tumor progression. With better diagnostic techniques we are now able to detect micrometastases at the single cell stage in lymph node biopsies. But what is the next step? Removing even a few lymph nodes could decrease the patient’s quality of life dramatically and not all lymph node micromets will progress beyond the lymph node. At the same time, metastatic cancer is cause for alarm. Q. If mets reach a dead end at lymph nodes, why remove them at all? A. It’s controversial. There’s evidence to suggest that 95% of malignant cells in the lymph node won’t go anywhere further, there’s also evidence to suggest the contrary. How aggressive a treatment should be used then? (slides) 2007 Cancer Statistics from the American Cancer Society Don’t have to memorize these percentages, just have a general sense of trends and the mechanisms used to delineate them. Change in death rates by cause
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This note was uploaded on 07/21/2008 for the course BIMM 134 taught by Professor Johnson during the Spring '08 term at UCSD.

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REVISED6-03-08Notes - Lecture #19 Tuesday, 6/3/08 -1-...

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