Lecture 2-3 - Lecture 2-3 Behavioural measures of neural plasticity of rodents Fear Conditioning o 3 important components of training tone cue

Lecture 2-3 - Lecture 2-3 Behavioural measures of neural...

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Lecture 2-3 Behavioural measures of neural plasticity of rodents Fear Conditioning: o 3 important components of training: tone cue, associated with US (shock) o Chamber represents lots of diffused cues that have little contiguity (no clear temporal association), not a lot of contingency b/w contacts and shock either b/c temporal order of these cues is complication (contact is there before shock), not as predictive as tone cue which is there right before shock occurs o Short 6 minute training in which animal can learn; one thing they learn is the context (chamber itself), put back in very same chamber and same contextual cues; difference b/w context test and training is there is no tone cue and no shock o the other test you can do is cue test which is different color and has different contextual cues, only thing that’s same b/w cue test and training is the tone cue (conditioned stimulus) o Cue test is associated memory test (associated tone with shock); context test tests if associated context with shock Variations of Fear Conditioning: o What’s wrong with B? you can’t rule our general anxiety: doesn’t mean animal learned, he might be more afraid of any kind of place it’s placed, may not remember that place but just remembers unconditioned stimulus sensitization o unless you have context discrimination you don’t know if something enhanced response o we don’t exactly what the animal learned; they may have learned from any or many of the cues (tactile, etc.); even if you do context discrimination you can’t tell if animal learned o if the animal learned that context 1 (certain tactile stimulation) is associated with shock, it is non-hippocampal learning, non-associative learning, it’s simply US-CS learning; only learned ONE cue, not contextual learning, which wasn’t your goal o salient stimuli: you associate it with unconditioned stimulus much more, the floor in context 1 is more salient; in salient cue you’re unlikely to associate background stimuli; tells rat that this is the best predictor of the shock; animal won’t have ability to pick out something from background
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o if you have lesioned hippocampus, you won’t be able to learn another cue that would associate w/ the shock, but they’ll still do test B very well, but you don’t know what cue they associated with o problem with learning tasks is that you have to compare different parts to interpret what’s happening; you’re measuring performance of animal and many things can interfere w/ its performance; you need multiple controlled experiments o Only A rules out the 3 factors: Motivation, CS-US ass learning, or contextual-hippocampal dependent learning Fear Conditioning Automated Recording: Many differences b/w context A and B Fear conditioning: foreground & background o
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  • Spring '17
  • Cue, ICR, tone cue

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