bmb428_problemset16 - BMB428 Physical Chemistry with...

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BMB428 Dr. Song Tan Physical Chemistry with Biological Applications Fall 2007 1 Problem Set 16: Bioenergetics Due Oct 25, 2007 1. Problem 6.29 (p. 232): The reaction L-glutamate + pyruvate α -ketogluarate + L-alanine is catalyzed by the enzyme L-glutamate-pyruvate aminotransferase. At 300 K, the equilibrium constant for the reaction is 1.11. Predict whether the forward reaction (left to right) will occur spontaneously if the concentrations of the reactants and products are [L-glutamate] = 3.0 x 10 -5 M, [pyruvate] = 3.3 x 10 -4 M, [ α -ketogluarate] = 1.6 x 10 -2 M, and [L-alanine] = 6.25 x 10 -3 M. 2. The first step in glycolysis is catalyzed by the enzyme hexokinase: glucose + ATP glucose-6-P + ADP This reaction can be thought of as two coupled reactions (P i is phosphate): (1) glucose + P i glucose-6-P (2) ATP ADP + P i For the overall reaction, G° = -16.7 kJ/mol. For the hydrolysis of ATP (equation 2), G° = -31.0 kJ/mol. All reactions are performed at 37°C. (a) What is G° for reaction 1? (b) What is [] glucose 6 P [glucose][phosphate] −− if G = 0? (c) Starting with 1 M glucose and 1 M phosphate, what are the equilibrium concentrations of
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This note was uploaded on 07/23/2008 for the course BMB 428 taught by Professor Tan during the Fall '07 term at Pennsylvania State University, University Park.

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