bmb428_problemset27 - Why? 3. Problem 10.22 (p. 399) What...

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BMB428 Dr. Song Tan Physical Chemistry with Biological Applications Fall 2007 1 Problem Set 27: Allostery Due Dec 13, 2007 1. Problem 10.18 (p. 399) (a) What is the physiological significance of cooperative O 2 binding by hemoglobin? Why is O2 binding by myoglobin not cooperative? (b) Compare the concerted model with the sequential model for the binding of oxygen with hemoglobin. 2. Problem 10.20 (p. 399) Competitive inhibitors, when present in small amounts, often act as activators to allosteric enzymes.
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Unformatted text preview: Why? 3. Problem 10.22 (p. 399) What is the effect of each of the following actions on oxygen affinity of adult hemoglobin (Hb A) in vitro? (a) Increase pH, (b) increase partial pressure fo CO 2 , (c) decrease [BPG], (d) dissociate the tetramer into monomers, (e) oxidize Fe(II) to Fe(III). 4. Problem 10.24 (p. 399) When deoxyhemoglobin crystals are exposed to oxygen, they shatter. On the other hand, deoxymyoglobin crystals are unaffected by oxygen. Explain....
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This note was uploaded on 07/23/2008 for the course BMB 428 taught by Professor Tan during the Fall '07 term at Penn State.

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