BMB428Dr. Song TanPhysical Chemistry with Biological ApplicationsFall 20071Problem Set 19: Physical Chemistry of Proteins and DNADue Nov 6, 20071.Problem 16.17 (p. 636)How does hydrophobic interaction differ from both covalent and noncovalent bonds? What rolesdoes it play in protein structure and stability?2.Problem 16.18 (p. 636)As Figure 22.17 shows, the averagepitch of an αhelix is 5.4 Å. Assumingthis pitch to be the same for human hairand that hair grows at the rate of 0.6inch/month, how many turns of theαhelix are generated each second?(Assume that 1 month = 30 days.)3.Problem 16.28 (p. 636) rewordedConsider the formation of a dimericprotein2P →P2.At 25°C, ∆rH° = 17 kJ/mol and∆rS° = 65 J/K•mol. Is the dimerizationfavored at this temperature? Commenton the effect of lowering thetemperature. Can you suggest amechanism to explain "cold-labile"enzymes.4.Problem 16.29 (p. 636) rewordedThe cause and properties of sickle-cell hemoglobin (HbS) were discussed in Chapter 16. Under
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