bmb428_problemset19 - BMB428 Physical Chemistry with...

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BMB428 Dr. Song Tan Physical Chemistry with Biological Applications Fall 2007 1 Problem Set 19: Physical Chemistry of Proteins and DNA Due Nov 6, 2007 1. Problem 16.17 (p. 636) How does hydrophobic interaction differ from both covalent and noncovalent bonds? What roles does it play in protein structure and stability? 2. Problem 16.18 (p. 636) As Figure 22.17 shows, the average pitch of an α helix is 5.4 Å. Assuming this pitch to be the same for human hair and that hair grows at the rate of 0.6 inch/month, how many turns of the α helix are generated each second? (Assume that 1 month = 30 days.) 3. Problem 16.28 (p. 636) reworded Consider the formation of a dimeric protein 2P P 2 . At 25°C, r H° = 17 kJ/mol and r S° = 65 J/K•mol. Is the dimerization favored at this temperature? Comment on the effect of lowering the temperature. Can you suggest a mechanism to explain "cold-labile" enzymes.
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This note was uploaded on 07/23/2008 for the course BMB 428 taught by Professor Tan during the Fall '07 term at Pennsylvania State University, University Park.

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