HW6a - Chem 476 HW 6(`ITN Due"Oxygen binding Name Please...

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Chem 476 HW 6 (‘ITN’) Due Oct 10, 2007 “Oxygen binding” Name:________________________ Please complete all questions. Do your work on additional sheets of paper and staple to the back of this sheet. Do not put your answers on this page. You may work with your classmates on this and all homework assignments. I will grade the same three questions for all students and post the answers to the questions after they are due. I.) Problems from the textbook and supplement (do not hand in). Answers are in the textbook (short answers) and supplement (full answers to text AND supplement), but work through on your own first. : Text: 7.1, 3-9 Supp: 7.1, 3, 4, 6, 7, 9, 10, 14. II.) Additional Problems to hand in : 1.) Consider a simple model of dioxygen binding to myoglobin (‘Mb’): Mb (aq) + O 2 (aq) = Mb*O 2 (aq) (‘=’ means reversible binding) a.) Write down the association constant, K a , and give its units. K a = [Mb*O 2 ] [Mb][O 2 ] Units of M -1 (=M/(M*M)) b.) Write down the dissociation constant, give its units, and relate K d to K a K d = [Mb][O 2 ] [Mb*O 2 ] Units of M (=M*M/M) K d =1/ K a c.) Biochemists typically prefer to work with K d s (which is foreign to most chemists). What is the main advantage of the K d format? (You may find this easier to answer after working the parts below). Advantage is that K d is the concentration of substrate needed to saturate half the sites in the macromolecule. That
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HW6a - Chem 476 HW 6(`ITN Due"Oxygen binding Name Please...

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