Chemistry 476 (Biological Chemistry)
Due: Monday December 3, 2007
This is a take-home exam, which counts as 20/130
of your final grade. It is based largely on
reading and understanding a paper from the literature on enzymology and teaching ourselves
some nucleotide biosynthesis (Chpt 25 from BTS). You are welcome to use any books or
Internet resources, but should reference them as appropriate in your answers. You cannot
consult with another person, including your classmates or other professors or students. There are
12 questions worth a total of 172 points. Please attach pages with your answers and initial the
top of each page.
I understand and attest that I have followed these guidelines.
(The two papers are posted on the class website.)
Purine Nucleoside Phosphorylase: Catalysis, Structure, and
Inhibition” Taylor, E. A., Rinaldo-Matthis, A., Ghanem, M., Hazelton, K., Cassera, M. B., Almo,
S. C., and Schramm, V. L. (2007)
“Enzymatic Transition State Theory and Transition State Analogue Design”
Schramm, V. L. (2007)
J. Biol. Chem. 282
: Berg, Tymoczko, and Stryer. “Biochemistry” 6
ed. Chpt 25.
1.) (12) Define these terms:
Feel free to use other resources and to work together, but give your
source and any url used. Do NOT just copy the answer from somewhere and put quotes around
it. Do say it in your own words then give the reference.