Exam1_old - Chemistry 476 (Biological Chemistry)...

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1 Chemistry 476 (Biological Chemistry) Examination 1 October 5, 2006 Name: ___________________ ____________________ (First) (Last) You have 80 minutes. Do all work on these pages. It is in your best interests to be as clear and complete as possible, but you should avoid spending too much time on any one problem. You should answer them in whatever order is best for you. There are 22 questions worth a total of 291 points. This exam counts as 20/130th of your final grade. Please initial the top of each page. 1.) (10) Draw a GC base pair. Show just the bases. In place of the sugar, use ‘R’. You should number the atoms in the bases and show all hydrogens and all hydrogen bonds. Label the glycosidic bond with the label ‘glyc’. 2.) (15) Amino acids a.) Draw your favorite basic amino acid b.) Draw your favorite acidic amino acid c.) Draw your favorite aromatic amino acid and show one resonance structure
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2 3.) (9) Consider the spontaneous formation of helical DNA from two complementary strands at 37 o C. What is the algebraic sign for the following thermodynamic parameters? Circle your answer. a.) Δ H positive negative zero can’t say b.) -T Δ S positive negative zero can’t say c.) Δ H-T Δ S positive negative zero can’t say 4.) (15) The following DNA oligonucleotide was placed in a test tube at 37 o C. The solution contained HEPES pH 7.0 (a buffer) and 100 mM NaCl, in a volume of 100 μ L and a DNA concentration of 1 mM. State whether the sequence will spontaneously form a duplex. Give the secondary structure of the duplex if there is one. a.) TCAGAAGACT b.) Repeat for the following sequence: GGAAGCTTCC 5.) (12) Draw a timeline for biochemical evolution. Your timeline should include dates for the following events. You can just write the letter corresponding to the given event. a.) Eukaryotes evolved b.) Dinosaurs evolved c.) The Big Bang (winner of 2006 Nobel Prize in Physics) d.) Prokaryotes evolved e.) Macroscopic organisms f.) Humans evolved ----------------------------------------------------------------------------------------------------------------->
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3 Time (in billions of years)
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This note was uploaded on 07/23/2008 for the course CHEM 476 taught by Professor Bevilacqua,philip during the Fall '07 term at Penn State.

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Exam1_old - Chemistry 476 (Biological Chemistry)...

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