203f02_e1_key

203f02_e1_key - Chemistry 203 Lg (Fall 200 Last Name:...

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Unformatted text preview: Chemistry 203 Lg (Fall 200 Last Name: September 24 11:00-11:50 ." First Name: Prof. Charles E. McKenna ‘ Social Security # T.A:l z: INITIAL OF LAST NAME Please do not open this exam until you are told to do so. Write legibly to avoid confusion. GOOD LUCK ! ! Question # Points n 21-25 20 ude ' ature (1) Comparing bacteria and viruses: —Both have a nuclear membrane —Both have cell walls accines exist only against bacteria — oth can be targeted by the humoral immune system (2) The compound shown is: .. . O @1311? u Me /C\ -—Deoxyribose (part of DNA) R NH H,S —A drug that opens a “hole” in bacterial Infillme Me O H 'H COQH —a sulfa drug (5 (3) The original penicillin: -Was discovered by Fleming in the 1920’s —Was a much more effective antibiotic than sulfa drugs @311 of the above are true —Cannot be modified in any way without total loss of antibiotic activity (4) AIDS-linked diseases (opportunistic infections) Q include: —Anthrax @aposi’s sarcoma, a cancer —Bubonic plague —Smallpox (5) Differences between a copyright, trademark and patent: —A patent lasts indefinitely —-A patent can be renewed after 17—20 years 9 trademark can be renewed after 20 years _A drug structure can be copyrighted < C A, ‘7‘ (7) The first U. S. patent was signed by: -—Paul Ehrlich teve Jobs eorge Washington —Abe Lincoln (8) The ‘non—self’ part of viruses recognized by the immune system consists of: -proteins on the virus surface (“antibodies”) —viral genes —small molecules secreted by the virus (cytokines) teins on the virus surface (“antigens”) (9) In the USA, the AIDS epidemic has existed for about: — decade gm decades —50 years —Over 100 years (10) A gene: —Is a molecular code specifying a protein —Is made of DNA except in certain viruses (RNA) — : ‘ fined by triplets of “bases” (codons) fl of the above are true (11) Infection with HIV differs from smallpox virus infection in that: —HIV causes/immediate symptoms and death —Only smallpox virus infection is lethal —Sma11pox is easily cured by existing drugs @I usually does not result in serious disease for many years; smallpox causes eath or serious illness within a relatively short time (12) The primary immune response: _ -—Is responsible for what we call “being immune” to a disease we already had @ps us fight a disease for the first time. —becomes effective very rapidly (within a few hours of infection) —All of the above are true (13) A problem in creating an “AIDS vaccine” is: —Vaccinated people are likely to test “HIV-positive” —Attenuated virus in vaccine may revert and cause the disease — cine may not give long-term immunity due to virus mutation -—A1 of the above (14) “Sulfa” antibiotics form a class of drug that act by: —Punching a “hole” in bacterial membranes —Inactivating a bacterial enzyme for cell wall synthesis — locking DNA synthesis by bacteria — imicking a natural bacterial compound (PABA); competing for its enzyme (15) In the reaction: I. <9 R—NH2 + HCl ——-p~ R—NH3 + Cl A B C D Where A = “ecstasy” —Both A and B are acids -A is the acid, B is the base — 's the base, D is the acid fis the acid, A is the base (16) The compound shown is a type of: Polar Head Group —Nucleoside (pan of DNA) : —Penicillin — _Su1fa drug Hydrophobic Tlils Hydrophobic “nus @id (part of membranes) (17) The compound shown is —Coca' - spirin —Penicillin (18) This is a picture of part of two DNA chains in a double helix. The two chains are held together by (dashed lines in boxes): —Van der Waals bonds @ydrogen bonds -—Ionic Bonds —None of the above (19) I describe in a published article the structure of a new compound, how to make it, and mention that it may be useful to treat HIV (AIDS) infection. This disclosure eliminates the possibility of: (20) (21) (22) (23) (24) —A use (anti-AIDS) patent for this compound —A composition of matter patent —- process patent for making the compound 1 of the above An example of a pandemic that killed millions of people within a few years is: -Bubonic (“black”) plague, 14‘l1 century -—Cholera, 19‘h century -fluenza, earl 20th century of the above The st efficient path for transmitting HIV from an infected to an uninfected person is: od transfusion —Needle stick —Sexual contact —Coughing or sneezing Sal (“606”), the first synthetic antibiotic, was discovered —B andom screening of many compounds , —Serendipitously (by accident when a teardrop fell onto a plate of bacteria -By drug company research on a lead compound —Serendipitously (by accident) when a mold grew on a plate of bacteria Analgesic drugs represent drugs classified by: —Sites of action —-Target system ect of drug —Chemical structure H 3’ ' pH defined as: @us the log of the H+ concentration in water -55 M water —acidic {its value is above 7 —moles H+ per liter of water (25) In the picture of the HIV virus shown, —A = viral RNA, B = protein envelope —D = protein envelope, C = viral RNA —E = viral enzymes, A = target cell receptors rotein envelope, E = target cell receptors BONUS QUESTIONS (4 Points Max, 1 Point each) For anthrax, match up the left side with the correct answer on the right (don’t guess): — effective drug -skin contact or inhalation of spores - bacterial size -very large (5 u) - usual infection via ipro — danger level -very small (<lp.) ~Acyclovir thal (often) -non-lethal -sexual contact or needle sharing ...
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This note was uploaded on 07/22/2008 for the course CHEM 203Lxg taught by Professor Mc kenna during the Fall '07 term at USC.

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203f02_e1_key - Chemistry 203 Lg (Fall 200 Last Name:...

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