203f04_e1_key

203f04_e1_key - Chemistry 203 Lg (Fall 2004) Exam #1 Last...

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Unformatted text preview: Chemistry 203 Lg (Fall 2004) Exam #1 Last Name: September 21, 2004; 11:00—11:50 First Name: Professor Amy M. Barrios Student ID # Professor Charles E. McKenna T.A: KW INITIAL OF LAST NAME Please do not open this exam until you are told to do so. Write Iegibly to avoid confusion. GOOD LUCK ! ! I will observe the rules of Academic integrity while taking this exam. Student Signature Circle the most nearly correct answer. (4 Pts.) (1) Avogadro’s number is: — 1000A _ 1010 - 30,000 (2) If one atom of C weighs 12 and one atom of H weighs 1, how much does one molecule of CH4 weigh? - 18 - 5 - 12 (3) The compound shown to the right is: - cocaine 0 - a sulfa drug R_HN g__NHR. - aspirin H — penicillin O (4) “Amphotericin” antibiotics form a class of drugs that act by: - mimicking a natural bacterial compound (antimetabolite, PABA) - blocking DNA synthesis by bacteria - inactivating a bacterial enzyme for cell wall synthesis - punching a “hole” in bacterial membranes (5) 10 years ago, I discovered a new molecule that could cure AIDS, but then stopped working on that project. Now, a drug company wants to patent the molecule as a new AIDS drug. Can I stop them? - Yes, because I did the work first — Yes, because the invention is obvious - No, because the “prior art” had already been published (disclosed) (6) What distinguishes a good drug from a bad drug? - A good drug is not toxic at all - A bad drug has an LD50 of less than 10 mg/kg - A good drug has a low therapeutic index - None of the above (7) In the influenza epidemic of 1918-1919: - The mortality rate was 100% (every person infected with the virus died) - There were very few deaths in the USA - The first effective antiviral drug was used A “W” pattern of mortality was observed (young children, young adults and older people all died) (8) Three of these molecules are opiates and one is AZT, an anti-HIV drug. Circle AZT: (one of these things is not like the other...) H30 0 W3 0 (9) Antibiotics are drugs related by: - chemical structure — target system — site of action (10) Concerning copyrights, trademarks and patents: - a patent must be novel but need not have utility - a publicly disclosed drug structure cannot be patented ‘ - a drug synthesis can be trademarked - a drug name like Cialis is an example of a copyright 5‘ end a—A—\ (l 1) This structure to the right is a fragment of: (i) — a single purine O__l|3___0 0 G — a single pyrimidine AH — the sugar phosphate backbone of RNA Cl) T - the sugar phosphate backbone of DNA OZT-o OH 0 i c 0:}?— OH O I A 0:? O OH 3' end (12) HIV attacks which cells of the immune system: - B cells - T8 cells - macrophages (13) A problem in creating an “AIDS vaccine” is: — attenuated virus in vaccine may revert and cause the disease — vaccinated people are likely to test “HIV—positive” — vaccine may not give long—term immunity due to virus mutation — all of the above (14) The antibiotic penicillin acts b : - inhibiting synthesis of the bacterial cell wall — punching holes in the bacterial cell membrane - entering the bacterial cell nucleus and destroying DNA — all of the above (15) HIV virus is called a “retrovirus” because: - its genetic material is DNA not RNA — its genetic RNA must be converted to DNA in infected cells (RNA—>DNA; “backwards”) — it enters the attacked cell “backwards” - all of the above are true (16) “AIDS” stands for: — Auto Immune Deficiency Syndrome - Acquired Internal Diseases from Sexual contact - Acute Immune Deficiency Syndrome (17) Infection with HIV typically results in: - brief flu-like symptoms, followed by permanent latency of the virus and no effect on life span and well being — immunity to other viral infections A - onset of serious symptoms after u toll years or more — immediate life-threatening disease (18) The compound shown to the right is a: - component of bacterial DNA - prodrug of salicylic acid 3 Group - type of antibiotic - lipid component of a cell membrane lll H) drophobic Tails Hydrophobic Tails (19) Which of the following molecules is a component 0 DNA but NOT RNA? «\fvx NH2 0 CH H O=F.’-O-3 ( / \> A I O” N 'f o N m “AIM aw OH phosphate backbone adenine thymine ribose (20) The most effective method for transmitting HIV from anerson to a person is: U - blood transfusion - needle stick — sexual contact - coughing or sneezing (21) Which of the diseases listed below is NOT caused by a virus? - HIV - Influenza - Polio (22) AIDS-linked opportunistic infections include: - Kaposi’s sarcoma (cancer) - Bubonic plague — Polio - Anthrax (23) The first US. patent was signed by: - Samuel Adams - Benjamin Franklin — George Washington - Steve Jobs (24) Which of the following statements is NOT true about acids and bases: - An acid and a base can react to form a salt - An acid is a H+ donor — A base reacts with a salt to form an acid - Many drugs are bases (25) A drug has LD50 = 0.1 mg/kg in human beings. Assume an average weight of 60 kg. A dose of 25 mg (about 1/10 the size of an aspirin tablet) will be fatal to: - more than half of the people dosed - exactly half of the people dosed - less than half of the people dosed - none of the people dosed BONUS QUESTION: 5 points max A doctor prescribes 10 mg of morphine over 10 hours to a cancer patient. The nurse takes a morphine solution that is 50 mg of morphine per 1 L (1000 mL) of solution and sets up an iv. drip at a rate of 20 mL per hour. The molecular weight of morphine is 285 grams per mole. a) (2 points) What is the concentration (molarity in moles per liter) of the morphine solution used by the nurse? (credit will be given for setting up the answer correctly, even if you do not have a calculator) 50mm 9 3% My, mgxlo'w 1/ WWW“) a8?) b) (2 points) How much morphine (in mg) will the patient get over 10 hours? .OB’OL- Bbmga 51/»: £25.15 m5 L. \n h c) (1 point) Did the patient get the right dose, too much, or too little? WW (Mg; ...
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This note was uploaded on 07/22/2008 for the course CHEM 203Lxg taught by Professor Mc kenna during the Fall '07 term at USC.

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203f04_e1_key - Chemistry 203 Lg (Fall 2004) Exam #1 Last...

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