203f03_e1_key

203f03_e1_key - Chemistry 203Lg (Fall 2003) Exam #1 Last...

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Unformatted text preview: Chemistry 203Lg (Fall 2003) Exam #1 Last Name: September 23, 2003, 11:00-11:50 am. First Name: Prof. Charles E. McKenna Social Security # T.A: INITIAL OF LAST NAME Please do not open this exam until you are told to do so. Write legibly to avoid confusion. GOOD LUCK ! ! ' Maximum Question # Points Score Grader TOTAL - ‘ I will observe the rules of Academic integrity while taking this exam. Student Signature (1) AIDS has been recognized as a new infectious disease since shortly after: 1990 1980 1970 1960 Differences between a copyright, trademark and patent: A patent lasts indefinitely A patent can be renewed afier 17-20 years A copyright can be renewed every 20 years A trademark is renewable every 20 years The secondary immune response: Helps us fight a disease for the first time Makes possible what we call “being immune” to a disease we already had Is complete within minutes of an infection All of the above are true With respect to creating an “AIDS vaccine”, it is believed that: Vaccinated people are unlikely to test “HIV-positive” Attenuated virus in vaccine may revert and cause the disease A vaccine will give long—term immunity despite virus mutation All of the above are true HIV virus is called a “retrovirus” because: Genetic RNA must be converted to DNA in infected cells (RNA->DNA) In virus form, its genetic material is DNA not RNA It is much more primitive in structure than other viruses Once its genes are expressed in the host cell, viral messenger RNA is synthesized (6) "Amphotericin" antibiotics form a class of drugs that act by: — Mimicking a natural bacterial compound (antimetabolite, PABA) — Blocking DNA synthesis by bacteria — Inactivating a bacterial enzyme for cell wall synthesis a Punching a "hole" in bacterial membranes (7) HIV causes collapse of the immune system by directly attacking: a T4 helper cells which coordinate the immune response ‘ — Antibodies produced by B cells — Antibody-producing B cells — Red blood cells (erythrocytes) (8) The genetic code is based on a 3-base triplet, like A-A-A, etc. Suppose the code was based on a 4-base quadruplet, then the maximum total number of codes is: (remember, there are four bases: A, T, C, and G.) — 16 — 64 — 128 a 256 (9) The graphic below shows binding of a drug to its target bacterial enzyme site. What kind of binding groups should be present in the active site? An —NH2 or —OH group A benzene ring or similar hydrophobic group _ A group with a (+) charge OAR of the above (10) The drug shown is: — Morphine O Heroin, a prodrug of morphine — Cocaine — Ecstacy (MDMA) (1 %: AIDS-linked diseases (opportunistic infections) do NOT include: holera Shingles — CMV retinitis —— Kaposi’s sarcoma (12) The most efficient path for transmitting HIV from an infected to an uninfected person is: — Needle stick — Pregnant mother to fetus — Two sexual contacts in a row a Blood transfusion (13) “pH” is defined as: - 10'7 M [11*] in water — grams H+ per liter of water — acidic if its value is above 7 in water 0 minus the log [H] in water 4 SARS — pidemics were so far controlled by quarantines — Epidemics were so far controlled by a new drug, fluoxetine — Is caused by a new staphylococcus bacterium — Is similar in contagiousness to HIV infection (15) In the influenza epidemic of 1918-19: — The mortality rate was ~100% — There were negligible deaths in the USA — The first effective antiviral drug was used a USA life expectancy was decreased to Civil War era levels (16) Drug resistance by an RNA virus is due to: Random changes in the RNA sugar (ribose) backbone Random changes in the RNA bases Changes in the drug structure caused by the virus Random changes in the RNA phosphate backbone Concerning copyrights, trademarks and patents: A patent must be novel but need not have utility A publically disclosed drug structure cannot be patented A drug synthesis can be trademarked A drug name like Cialis is an example of a copyright Analgesics are drugs related by: Pharmacological effect Chemical structure Site of action Target system (19) A drug has toxic dose TD50 = 1 mM and effective dose ECSO = 0.1 14M. Its therapeutic index is: — 0.1 ~ 10 a 10,000 — 0.0001 (20) A drug has LD50 = 0.1 mg/Kg in human beings. Assume an average weight of 60 Kg. ccidental dose of 25 mg (about the 1/ 10 the size of one aspirin tablet) will be fatal to: > 1/2 the people dosed Exactly 1/2 the people dosed < 1/2 the people dosed None of the people dosed . o g . .. ® (21) R-NI-Iz + HCI ——-> R-NHs + A n c D For the reaction shown above, which is NOT correct? -— B is a stronger acid than C Q A will be more soluble in water than C/D — A is acting as a base - C/D is more likely to be a crystalline solid than A (22) The compound shown is a: — Component of bacterial DNA — Prodrug of salicylic acid . . . Hm «fa-gm. — Type of antibiotic rm a“; Lipid component of a cell membrane 5 lbw hi“ a "WWII (23) In the diagram of HIV shown: — C = viral RNA, D = target cell receptors 0 B = viral RNA, C = viral enzymes — D = protein envelope, A = viral RNA — A = cell wall, E = viral enzymes (24) The drug shown is: - Aspirin — Prontosil (sulfa prodrug, dye) R-NH_©rg—NHR" — Salvarsan (“3 a Sulfa (25) DNA vs. RNA — DNA has U instead of T — DNA has an extra (2’) OH in its sugar moiety — DNA is less stable @None of the above is correct BONUS QUESTION (4 Points Max, 1 Point each) fig. 14.34 Permeability barflerof a Gum—negative bacterial cell. The picture above illustrates the molecular basis for bacterial cell resistance against a certain drug. ‘ a) Namethe drug. “L, b) On the basis of the diagram, explain three different ways the cell defends itself against this antibiotic. (WW) Please give me your comments on the class so far: Lectures: Lab: Web page: How can we improve the class? What do you like? Comment on TA? Thanks for your input, Professor Charles McKenna & the Chem 203Lg Staff ...
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203f03_e1_key - Chemistry 203Lg (Fall 2003) Exam #1 Last...

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