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problem_set_4 - 2 required for any given fraction of...

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Problem Set #4 BMB 401 Spring 2003 Problems from Lehninger: 1, 2, 3, 4, 6, 7, Problem 1 – Identify the distal and proximal histidines in hemolglobin / myoglobin, and summarize their roles in the respective protein’s function. Problem 2 – Explain from a structural standpoint why oxygen binding to hemoglobin shows cooperativity, while oxygen binding to myoglobin does not. Problem 3 – The oxygen binding curve for hemoglobin is shown below. In the presence of CO 2 , the partial pressure of O
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Unformatted text preview: 2 required for any given fraction of saturation is increased. Suggest an explanation for this effect. Problem 4 – Typical Hill plots are sigmoidal in nature, with the extreme ends showing slopes of 1, indicating no cooperativity. Explaing why this is the case. Problem 5 – The slope of a Hill plot is 3.0 and the intercept on the ordinate is –0.6021. Calculate the Hill coefficient and the apparent dissociation constant....
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