203f07_e3_key

203f07_e3_key - Chemistry 203 Lg (Fall ‘07), Exam #3 Last...

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Unformatted text preview: Chemistry 203 Lg (Fall ‘07), Exam #3 Last Name: November 20, 2007; 11:00-11:50 am. First Name: Prof. Charles E. McKenna USC ID: Prof. Richard Brutchey NITIAL OF LAST NAME Please do not w pen this exam until you are told to do so. Write leginy to avoid confusion. GOOD LUCK ! ! Question # Bonus 1 4 TOTAL ' 104 I will observe the rules of Academic integrity while taking this exam. & Student Signature Circle the most nearly correct answer. (4 points each) 1. A drug taken orally, to be effective, must: a) Resist stomach acid b) Be absorbed by the gastrointestinal tract c) Resist being broken down by the liver 6) All of the above 2. Which of the following statements regarding a drug is true? a) It cannot be too lipophilic b) It may be inactivated by liver enzymes that oxidize RCHZOH groups to RCH3 groups c) It needs to be positively charged to cross cell membranes @\I one of the above are true 3. In order to design a more effective drug, we might consider changing the parent drug structure’s: a) Sterics b) Electronics c) Hydrophobicity @ll of the above 4. A series of drug analogues A, B, and C had partition coefficient (P) values of: A, 0.1; B, 1; C, 2 10. The effective concentrations (C) for activity were: A, 100; B, 1; C, 0.01. del/ WThe results show that: If M" L l :H MW (1 QV A more hydrophobic analog has greater activity b) A more hydrophilic analog has greater activity c) A plot of log(l/C) vs. log(P) will have a negative correlation d) The hydrophobicity of the drugs has no effect on their activity 5. Drugs with amine groups will often cross cell membranes in their form and bind to a receptor in their form. a) Demethylated, methylated b) Ionized,non-ionized @Non-ionized, ionized d) None of the above 6. In QSAR plots, the relationship between log(l/C) and log(P) is: a) Always linear / b) Always nonlinear / c) Not derived from experimental data /' / W @me of the above are true 7. A prodrug: a) Is an active drug that is converted into an inactive drug in the body b) Is a highly polar or ionic derivative of a less polar drug @Is an inactive form of the drug that is converted into an active drug in the body d) Is a toxic form of the drug 8. A “double blind” study of a new drug means that: 6/ Neither subjects nor doctors know who is receiving drug or placebo b) Subjects but not doctors know who is receiving drug or placebo 0) Doctors but not patients know who is receiving drug or placebo d) Both doctors and subjects know who is receiving drug or placebo 9. The standard deviation measures the spread of data about the mean. If the data are distributed randomly around the mean, then: a) 95% of all the results are +/— I o of the mean L133) 95% of all the results are +/- 2 o of the mean c) 95% of all the results are +/— 3 o of the mean d) 95% of all the results are +/— 4 o of the mean 10. Drugs are mainly metabolized in the: a) Stomach b) Intestines 6) Liver d) Kidneys 11. A drug is tested and found to (apparently) decrease the mean HIV viral level in a sample group. The t value calculated from the data is 3.7. The approximate probability that the drug is effective is: a) 95% if 2 persons participated b) 97.5% if 3 persons participated c) 99% if 10 persons participated d) 9.5% if 7 persons participated 12. The effects of a new bronchial inhaler were tested on a group of 40 asthma patients. After administering the inhaler, the patients lung capacity increased by an average of 1.5 liters = 7). What can we conclude? ‘ g 0 a) e can say with less than 95% confidence that the inhaler is effective 2 =- I .7 b) We can say with about 97 5% confidence that the inhaler is effective /9 ‘4“ c) We can say with greater than 99.9% confidence that the inhaler is effective 9' t I - '7 (0 d) We do not have enough information to determine whether the inhaler is effective or not A b)B c)C d) The r2 values are all equally close to 1 13. Wh'ch trend line above has an r2 value closest to l? 14. Which of the following is not one of Lipinski’s Rule of Five? a) A molecular weight less than 500 b) No more than 5 H—bond donor groups c) N o more than 10 H-bond acceptor groups A partition coefficient greater than 10 15. Which of the following areas apply to the study of pharmacokinetics? i) Drug efficacy; ii) Drug metabolism; iii) Drug excretion; iv) Drug absorption a) All of the above GD ii, iii, and iv c) iii and iv d) iv only 16. A problem in shortening the time devoted to the Phase II - Phase III clinical trials of an AIDS drug is: a) May not have time to establish optimal dosage b) May not get any results on efficacy c) Precludes double—blind study @ong—term side effects may be missed 17. Which one of the following is correct? a) Phase I clinical trials typically involve 100-300 people b) Phase III clinical trials usually take about 1 year @ Phase III clinical trials assess both drug efficacy and side effect d) Both Phase II and Phase III clinical trials are typically single—blinded 18. Key difference between subjects in Phase I vs. Phase II is: a) Phase I subjects are ill, Phase II subjects are healthy Phase I subjects are healthy, Phase II subjects are ill c) More subjects in Phase I (all ill) d) More subjects in Phase II (all healthy) 19. According to Dr. Ebetino, which of the following statements regarding risedronate are true? i) It is used to treat osteoporosis; ii) The drug is mainly targeted to adolescents; iii) The drug contains a pyridine functional group; iv) The patent for this drug is held by Pfizer a) ii, iii and iv b) i,iii,and iv @ and iii d) i and iv 20. A g company gets an IND approval for its hot new drug from the FDA. It is now: a) eady to start a Phase I clinical trial b) Ready to start a Phase II clinical trial c) Ready to start toxicology studies in an animal model d) Ready to sell the drug on the market 21. AZT works to combat HIV by: a) Inhibiting viral protein synthesis b) Blocking viral polyprotein cleavage c) Preventing incorporation of viral DNA into the host cell genome @Inhibiting viral reverse transcription 22. The “AIDS drug” shown is: H O NRTI 3) CH3 N @NNRTI . .. / \ / \ c) Protease inhibitor \ >\ _ N \ _ N d) Peptide analogue N 23. Protease inhibitors: a) Target HIV penetration of the host cell b) Target reverse transcription T get viral DNA translation d) ock generation of HIV structural and enzyme proteins during formation of new viral particles , 24. According to Professor Wang, which of the following statements are true? i) Natural products are used by an organism to gain survival advantage over others; ii) An organism can use natural products as a chemical defense mechanism; iii) Natural products are commonly found in trees and plants; iv) The most pharmacologically effective natural products have already been discovered a) iand ii b) ii and iii 9 i,ii,and iii d) All of the above are true 25. Which of the following statements are true? i) Metabolites are typically less polar than their parent drugs ii) The body metabolizes drugs so that they can be excreted iii) Both polar and non-polar molecules are excreted in the kidneys iv) Metabolism occurs via oxidation, reduction, and hydrolysis reactions a) All are true b), iand iii ii and iv d) i,ii,andiv BONUS! 4 extra points Identify the following drugs by any one of the following: - Chemical abbreviation - Generic name - Trade name ...
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This note was uploaded on 07/22/2008 for the course CHEM 203Lxg taught by Professor Mc kenna during the Fall '07 term at USC.

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203f07_e3_key - Chemistry 203 Lg (Fall ‘07), Exam #3 Last...

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