Lecture_March_07_2

Lecture_March_07_2 - I. The migration and differentiation...

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I. The migration and differentiation of neural crest cells 1. Origin of neural crest cells
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Vagal neural crest Sacral neural crest Parasympathetic nerves of the gut
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2. Properties of neural crest cells
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Movie: Migration of neural crest cells in the hindbrain region.
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3. Migration of trunk neural crest cells
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a. Initiation of neural crest cell migration BMP4/7 +Wnt6 N-cadherin FoxD Slug RhoB
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b. Molecules that promote and direct the migration of neural crest cells -Attractive signals: extracellular matrix (ECM) proteins ECM proteins: -Fibronectin -Laminin -Collagen -Proteoglycan -Thrombospondin
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Movie: Cardiac neural crest-precursor tissue (neural tube) from stage 10+ chick embryo hindbrain on a fibronectin-coated tissue culture dish. Images were captured every 3 min. The original neural tube explant is the cylindrical object oriented in the vertical plane. By P.R. Brauer.
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-Repulsive signals from the posterior portion of the somite
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anterior posterior Neural crest cells expressing neuropilin-2 Expression pattern of semaphorin 3F Semaphorin 3F is only expressed in posterior half of somites
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This note was uploaded on 07/23/2008 for the course BIOL 303 taught by Professor Nilson during the Winter '08 term at McGill.

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Lecture_March_07_2 - I. The migration and differentiation...

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