Lh5Ch16TCA

Lh5Ch16TCA - The Citric Acid Cycle Chapter 16 The Citric...

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Unformatted text preview: The Citric Acid Cycle Chapter 16 The Citric Acid Cycle Pyruvate Dehydrogenase Discovered CAC in Pigeon Flight Muscle Overall Picture Overall Picture Overall Picture This area should be same color as Stage 2. All this takes place in the Acetyl-CoA production occurs in the mitochondria mitochondria Pyr DH is a Complex Enzyme Remember HSCoA ? Lipoic Acid is linked to a Lys (K) Pyr DH in TEM One Unit of Pyr DH Pyr DH is a Cool Enzyme Citrate Synthase Convention to write incoming Acetyl on Top Citrate Synthase without Substrates Citrate Synthase with Substrates Aconitase, the Ferris Wheel Aconitase has More than One Role Mitochondrial aconitase: Citric Acid Cycle Cytosolic aconitase: 2 roles: 1. citrate isocitrate to generate NADPH 2. iron response regulator To become an iron response regulator, aconitase changes it shape (due to lack of iron) so it can bind RNA. Isocitrate DH Mn ++ cofactor G o = -21 kJ/mole KG DH is Just Like Pyr DH HUH?? Succinyl CoA Synthetase : Substrate Level Phosphorylation Succ Synthetase Rxn Succinate DH = Old Yellow Remember Malonate was Our First Competitive Inhibitor Fumarase Dont Confuse Malate and Maleate Malate DH is Endothermic Watch Where the Label Goes Citrate is Prochiral...
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This note was uploaded on 07/24/2008 for the course BCH 3033 taught by Professor Makemson during the Summer '08 term at FIU.

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Lh5Ch16TCA - The Citric Acid Cycle Chapter 16 The Citric...

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