hw3 - BIOE 398BS: Quantitative Human Systems Physiology...

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BIOE 398BS: Quantitative Human Systems Physiology Spring 2008 Bioengineering, University of Illinois at Urbana-Champaign 1 Problem Set 3. Due Friday, Feb. 8, 2008. 1. A cell has a steady-state ionic distribution across its plasma membrane at 298 K as follows: Inside (mM) Outside (mM) Conductance ( μ mho/cm 2 ) K+ 110 3 250 Na+ 15 125 5 Cl- 25 100 100 q = 1.6 x 10 -19 coulombs, kT/q = 25 x 10 -3 volts. Note: μmho = 10 -6 (coulomb/sec)/volt, a mho is the basic unit of conductance (the reciprocal of resistance, measured in ohms), the coulomb is a standard unit of charge. A. Calculate the Nernst equation (or Nernst potential) for each of these ions B. Calculate the cell’s resting membrane potential using the chord conductance equation. Is inside positive or inside negative relative to outside? C. Next, the cell is exposed to a new drug that is known to affect the conductance of membrane ion channels. Upon exposure to this drug, the cell’s membrane potential depolarizes. Propose three different conductance changes that could
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This note was uploaded on 07/24/2008 for the course BIOE 398 taught by Professor Bioe during the Fall '07 term at University of Illinois at Urbana–Champaign.

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hw3 - BIOE 398BS: Quantitative Human Systems Physiology...

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