Lecture+10_2017 - 1 How was Exam 2 A Better than Exam 1 B...

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How was Exam 2? A) Better than Exam 1 B) Worse than Exam 1 C) About the same 2
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Sensory neurons are specified by which of the following? A) High BMP, low Shh B) High BMP, low Nodal C) Low BMP, high Shh D) Low BMP, high Nodal 3
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Where does skin come from? A) ectoderm B) mesoderm C) both D) neither 4
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Where does hair come from? A) ectoderm B) mesoderm C) both D) neither 5
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1. What is skin? 2. How do we make hair? 6
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1. What is skin? a. Origins & composi:on b. Development c. Diseases 2. How do we make hair? 7
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epidermis kera2nocytes in stra2fied epithelium dermis basal layer fibroblasts zygote ectoderm mesoderm endoderm neural non-neural CNS neural crest melanocytes Paraxial mesoderm somite dermatome fibroblasts periderm epidermis basal cells melanocytes 8
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1. Periderm 2. Stra2fied epithelium 10
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Blanpain and Fuchs, Nat Rev Mol Cell Biol, 2009 K14 + 11
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Epidermolysis bullosa Alopecia 13
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Fibroblasts iPSCs homologous recombina2on to replace K14 mutant with K14 wt differen2ate to kera2nocytes transplant A possible solu2on: 14
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1. What is skin? a. Origins & composi:on b. Development
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