PPT_Chapter_26_Karch - Narcotics Narcotic Antagonists and Antimigraine Agents Chapter 26 Copyright 2013 Wolters Kluwer Health | Lippincott Williams

PPT_Chapter_26_Karch - Narcotics Narcotic Antagonists and...

This preview shows page 1 - 11 out of 50 pages.

Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Narcotics, Narcotic Antagonists, and Antimigraine Agents Narcotics, Narcotic Antagonists, and Antimigraine Agents Chapter 26
Image of page 1
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Pain Pain Definition Sensory and emotional experience associated with actual or potential tissue damage Drugs Used to Relieve Pain Narcotics: Opium derivatives used to treat many types of pain Antimigraine Drugs: Reserved for the treatment of migraine headaches
Image of page 2
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Neural Pathways of Pain
Image of page 3
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Gate-Control Theory of Pain Gate-Control Theory of Pain
Image of page 4
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Location of Opioid Receptors Location of Opioid Receptors CNS Nerves in the periphery Cells in the gastrointestinal (GI) tract
Image of page 5
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Narcotic Agonists Narcotic Agonists Actions Act at specific opioid receptor sites in the CNS Produce analgesia, sedation, and a sense of well- being Indications Relief of severe acute or chronic pain Analgesia during anesthesia Cross placenta
Image of page 6
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Narcotic Agonists (cont.) Narcotic Agonists (cont.) Pharmacokinetics IV most reliable way to achieve therapeutic response IM and sub-q rate of absorption varies Hepatic metabolism and generally excreted in the urine and bile Contraindications Known allergy Pregnancy, labor, lactation Diarrhea caused by poisons
Image of page 7
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Narcotic Agonists (cont.) Narcotic Agonists (cont.) Cautions Respiratory dysfunction GI or GU surgery Acute abdomen or ulcerative colitis Adverse Reactions Respiratory depression with apnea Cardiac arrest
Image of page 8
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Narcotic Agonists (cont.) Narcotic Agonists (cont.) Adverse Reactions (cont.) Shock Orthostatic hypotension Nausea, vomiting, constipation Biliary spasm Dizziness, psychoses, anxiety, fear, hallucinations Drug-to-Drug Interactions Barbiturate general anesthetics, phenothiazines, and MAOIs
Image of page 9
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Image of page 10
Image of page 11

You've reached the end of your free preview.

Want to read all 50 pages?

  • Winter '15
  • beth cofini
  • Wolters Kluwer Health, Lippincott Williams & Wilkins

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture