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Memory at Neural Level - Memory Neural Level How does...

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Memory – Neural Level
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How does Learning Occur at Neural Level? • Donald Hebb (1904 – 1985) – Neurons that fire together, wire together (1949). – Hebbian learning • Unsupervised • Increase in synaptic strength when two neurons both active.
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First Experimental Evidence • Bliss & Lomo (1973) • Long­Term Potentiation (LTP) – Initially shown in rabbit hippocampus – Rapidly repeating injection of current into axon causes increased post­synaptic response (increased EPSP in dendrites of post­synaptic cell).
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LTP ­ Evidence Tetanus: sequence of 100 test stimuli, 10 ms apart. Rectangles: response in dendrite to test stimulus – a current pulse into axon lasting 100 us. (Post­Tetanic Potentiation)
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LTP ­ Specificity dendrites axons ++ : strong tetanus ++ ­­ : no tetanus ­­ LTP No LTP
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LTP ­ Cooperativity ~~ ­­ NO LTP NO LTP ~~ : weak tetanus ~~ ~~ LTP LTP ­­ : no tetanus ­­ No LTP
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LTP – Nitty Gritty
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