Excedrin Lab

Excedrin Lab - Gloria Park Hye Oh Excedrin Lab Purpose The...

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Gloria Park, Hye Oh Excedrin Lab Purpose: The purpose of this lab was to isolate and purify the components of an extra strength Excedrin tablet using a combination of solubility differences and a chemically active extraction. Abstract: The R f values of the components of the Extra Strength Excedrin tablet were found to be: acetaminophen (0.37), aspirin (0.68), and caffeine (0.21). The melting points for the three components were found to be: 162°C for acetaminophen, 148°C for aspirin, and unknown for caffeine. . Introduction: Extra Strength Excedrin is an over the counter pain reliever that contains a binder and three ingredients: acetaminophen (4-acetamidophenol), aspirin (acetylsalicylic acid) and caffeine. The separation and isolation of all three active components requires various steps. Chemically active extraction is a liquid-liquid extraction that separates components based on their solubility. In a chemically active extraction of a compound is chemically altered to change its solubility in a solvent. This is done by acid-base reactions. Thus, this extraction method is commonly referred to as an acid base extraction. Crystallization is a technique used to further purify compounds. When a solution is heated and then allowed to cool slowly, crystallization of the pure substance results. The formation of crystals in solution separates out a pure compound while impurities usually remain in solution. If the solution is cooled too quickly, the crystals will be smaller and trap impurities. Thin Layer Chromatography (TLC) is a process that can be used to test the purity of the separated compounds. This is done by spotting a sample at the bottom of a TLC plate and then placing the plate in a shallow amount of developing solution. The spots on the plate are then visualized by using UV light.
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This note was uploaded on 08/01/2008 for the course CHEM 241L taught by Professor Hunt during the Spring '08 term at UVA.

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Excedrin Lab - Gloria Park Hye Oh Excedrin Lab Purpose The...

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