01 - MCB 140 General Genetics MCB140, Jan. 23, 2008 1...

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MCB140, Jan. 23, 2008 1 MCB 140 – General Genetics
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MCB140, Jan. 23, 2008 2 Cancer Free at 33, but Weighing a Mastectomy” The New York Times, Sunday, Sep. 16, 2007 Deborah Lindner, 33, did intensive research as she considered having a preventive mastectomy after a DNA test.
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MCB140, Jan. 23, 2008 3 The New York Times, Sunday, Sep. 16, 2007 60-80%
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MCB140, Jan. 23, 2008 4 The New York Times, Sunday, Sep. 16, 2007
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MCB140, Jan. 23, 2008 5 Gregor Mendel (1822-1884), and his garden in Brno (Czech Republic)
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MCB140, Jan. 23, 2008 6 A Macy’s store in Vancouver, BC: socks, home appliances, genotyping “GeneBase” – CAN $300
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MCB140, Jan. 23, 2008 7 Nov. 17, 2007
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MCB140, Jan. 23, 2008 8 Single nucleotide polymorphism (SNP – pronounced “snip”): 1:1,000 11.25 11.7
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MCB140, Jan. 23, 2008 9
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MCB140, Jan. 23, 2008 10 Decode’s claim “Through a variety of sources, including deCODE genetics own pioneering research in population genetics, we have collected and annotated the most accurate and validated information available on genetic variations which have been associated with an average, higher or lower risk of common diseases. We will give you both detailed scientific background and the means to study how this knowledge applies to you. Our current list of diseases includes: Age-related Macular Degeneration, Asthma, Alzheimer's Disease, Atrial Fibrillation, Breast Cancer, Celiac Disease, Colorectal Cancer, Exfoliation Glaucoma XFG, Crohn's Disease, Multiple Sclerosis, Myocardial Infarction, Obesity, Prostate Cancer, Psoriasis, Restless Legs, Rheumatoid Arthritis, Type 1 Diabetes and Type 2 Diabetes. The disease list will be updated continuously as new discoveries are made.” Emphasis mine – fdu. My evaluation of said claim: Disingenuous (a definition from Merriam-Webster): lacking in candor; also : giving a false appearance of simple frankness : calculating
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MCB140, Jan. 23, 2008 11 A few terms from the “detailed scientific background” Haplotype Linkage disequilibrium Penetrance Expressivity Epistasis Norm of reaction Narrow-sense heritability Odds ratio
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MCB140, Jan. 23, 2008 12 Cancer: stage of detection P. Steeg Nature Medicine - 12, 895 - 904 ( 2006)
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MCB140, Jan. 23, 2008 13 “$300 to Learn Risk of Prostate Cancer” NYT Jan 18, 2008 “A combination of common and minor variations in five regions of DNA can help predict a man’s risk of getting prostate cancer, researchers reported* Wednesday. Men with four or five variants made up only 2 percent of the study population but had a 4.5-fold increased risk of having prostate cancer compared with men who had none of the variants. If the men also had a family history of prostate cancer, their risk was nearly 10 times higher than that of men with none of those risk factors. … A company formed by researchers at Wake Forest University School of Medicine is expected to make the test available in a few months, … . It should cost less than $300.” * “Cumulative Association of Five Genetic Variants with Prostate Cancer” Zheng et al. New England Journal of Medicine AOP 2008
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This note was uploaded on 08/01/2008 for the course MCB 140 taught by Professor Urnov during the Spring '08 term at University of California, Berkeley.

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01 - MCB 140 General Genetics MCB140, Jan. 23, 2008 1...

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