140-S08-Mar7 - Reading (to get a head start on next Wed's...

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Reading (to get a head start on next Wed's lecture) : “Transposable genetic elements move from place to place in the genome” pp508-514 (Chp 14) Also: p548 (insertion sequences in bacteria) A practice problem set dealing with mutant categories and material from today's lecture is available on the website. Answers will be posted next Wednesday. Add to reading: (for today) pp240-241 of text
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Approach for ovo D1 worked for Antp 32a5 and Ns 1 as well, two GOF mutant alleles that cause the antenna to develop as a leg . (I owe my own success to reverting dominant mutations) "revert" the dominance (one gets a recessive lethal in each case) …the resulting recessive lethal mutant chromosome(s) can be used in complementation tests
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Categorized with respect to: Mutations (changes in DNA): (1) change in gene function relative to wildtype (2) molecular nature (Chp 7 and a bit of Chp 8) (you'll probably need for the MCATs)
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Categorized with respect to: Mutations (changes in DNA): A) single base pair ( point mutation) transition ( Pur > Pur or Pyr > Pyr ) transversion ( Pur > Pyr ) frameshift (reading frame changed) missense (amino acid difference) nonsense (translation terminates) B) more than a single base pair pseudopoint (cytologically invisible, and small enough to make it hard to distinguish genetically from a point) chromosomal (enough to see cytologically) e.g. transposon insertions (2) molecular nature (Chp 7 and a bit of Chp 8) effect on translation kind of base change
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(2) molecular nature Categorized with respect to: Mutations (changes in DNA): (1) change in gene function relative to wildtype (3) Effect on organism
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This note was uploaded on 08/01/2008 for the course MCB 140 taught by Professor Urnov during the Spring '08 term at University of California, Berkeley.

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140-S08-Mar7 - Reading (to get a head start on next Wed's...

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