140-S08-Mar19 - The date for the review for the midterm has...

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Reading on sex: pp85-88 (In many species…) pp109-110 review (Analysis of rare mistakes…) pp516-518 (Changes in chrom. # --to--Some euploid…) Table 14.2 (p526) pp664-665 (RNA splicing helps regulate gene expression) pp669-676 except 670-71 (Sex determination in Drosophila…) The date for the review for the midterm has been changed to Thursday eve. (7-9p) April 10 since there is a conflict with a night exam on the 9th. I’ll announce where the session will be held as soon as I know myself.
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(1) genetically sensitize the system: “turn” lof recessives into dominants ( but only with respect to one non-essential aspect of their function) Poising the activity level of “your favorite gene” on a phenotypic threshold to make other genes that work with it in a regulatory pathway haploinsufficient …but only with respect to the functioning of “your favorite gene.” On Monday: So that: (1) we can identify new mutations of interest in the F1 generation (first generation after mutagenizing the parents) AND (2) can overcome some complications of pleiotropy …so that we can more easily study the non-vital aspects of the functioning of genes that ALSO have vital functions
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(1) genetically sensitize the system: “turn” lof recessives into dominants ( but only with respect to one non-essential aspect of their function) …if take away that cushion for any one gene in a pathway, now make the normal operation of the pathway …with respect to that one gene… more vulnerable to reductions in the levels of other gene products with which it works Wildtype organism must normally have an excess of most genes’ activity as insurance against fluctuations in the levels of activity of various genes in a pathway during development Based on the rationale that:
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(2) use targetted genetic mosaics to screen for recessives in the F1 (homozygous clones in heterozygotes …in non-essential tissues only!) …recover new recessives in the F1 without making them dominant !!! Another way around the limitations of pleiotropy in genetic screens: genetic mosaics
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genetic mosaics genetic mosaic vs : ( genetic ) chimera : cells …all derived from a single initial cell (zygote) individuals organism In your text's glossary: see: mosaics an organism containing tissues of different genotypes an embryo or animal composed of cells from two or more different organisms
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140-S08-Mar19 - The date for the review for the midterm has...

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