set3key - THIRD PROBLEM SET-KEY 1. + COONH3...

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THIRD PROBLEM SET-KEY 1. COO - + NH 3 -C-CH 2 -CH 2 -CH 2 -CH 2 -NH 3 + H COOH NH 2 -C-CH 2 -CH 2 -CH 2 -CH 2 -NH 2 H a. These groups have a proton and, because of the equilibrium (dissociation) constant of the reaction HA ->H + + A - , are likely to give it up under the conditions normally found in living things (i.e. pH 7) b. These groups, again because of their dissociation constants, are likely to pick up a proton under the conditions normally found in living things. c. At high pH (low H +) ,some groups that at normal pH might keep their proton, will lose it. Other groups which at normal pH might lose a proton, could gain one at very low pH where there are many more protons in the solution. COO - H 2 N-C-CH 2 -CH 2 -CH 2 -CH 2 -NH 2 H COOH H 3 N-C-CH 2 -CH 2 -CH 2 -CH 2 -NH 3 H d. At pH 8.9 and above, an amino acid on this protein (isoleucine) has its - NH 3 + group deprotonated (loses a proton). As a result it loses its + charge and becomes -NH 2 . Then it is no longer attracted to a nearby amino acid
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This note was uploaded on 08/01/2008 for the course MCB 11 taught by Professor Alper during the Spring '06 term at University of California, Berkeley.

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set3key - THIRD PROBLEM SET-KEY 1. + COONH3...

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