GENM0703 week3 - Lecture 19 Cell-Extracellular Matrix...

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Lecture 19 Cell-Extracellular Matrix Interactions Dr. Irina Voineagu D26 217B [email protected] Lecture 20 Cell-Cell Interactions: Cell Adhesion and Junctions
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Lecture Outline An introduction to cell-cell interactions The roles of cell adhesion molecules . Organisation of cell-cell junctions between sheet-like epithelial cells Tight junctions Adherens junctions (and cadherins) Desmosomes Gap junctions and plasmodesmata
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Cell adhesion Cell-cell adhesion (cells adhere directly to each other) and cell-matrix adhesion (cells bind to components in the surrounding extra-cellular matrix) both involve cell adhesion molecules (CAMs ). Cell adhesion is involved in: Maintenance of the form and structure of tissues, organs & organisms Communication between cells Organisation of tissues during development Cell migration
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The folks who discovered much of what we are discussing in the lectures on cell adhesion
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The folks who discovered much of what we are discussing in the lectures on cell adhesion Discovered a large protein molecule that was present on the surface of normal fibroblast cells, but absent in transformed tumorous fibroblasts
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The folks who discovered much of what we are discussing in the lectures on cell adhesion large external transformation-sensitive protein (LERTS) Fibronectin
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The folks who discovered much of what we are discussing in the lectures on cell adhesion In Kyoto: Trypsin dissociates cells and cells quickly re-associate In California: Trypsin dissociates cells and they remain dissociated
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The folks who discovered much of what we are discussing in the lectures on cell adhesion In Kyoto: Trypsin dissociates cells and cells quickly re-associate In California: Trypsin dissociates cells and they remain dissociated Medium contained EDTA, a Calcium chelator Ca-dependent cell adhesion molecules
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Cell Adhesion Molecules CAMs are transmembrane proteins with large extracellular domains. Cell-cell adhesion results from binding to CAMs on other cells. Adapters link CAMs to cytoskeletal components (actin or intermediate filaments).
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