Anaphylaxis is a systemic type I hypersensitivity reaction that can often have fatal consequences. Anaphylaxis can be caused by foods, latex, drugs, bee/wasp stings and venom. The number one most important intervention to give someone who is experiencing anaphylaxis reaction is epinephrine. If given immediately it can prevent a person from going into complete anaphylactic shock. Anaphylaxis begins in an individual after re-exposure to an antigen to which that person has produced a specific IgE antibody. The antigen to which one produces an IgE antibody response that leads to an allergic reaction is called an allergen (Johnson & Peebles, 2004). Allergen bound to IgE causes degranulation of mast cells which then release many vasoactive and inflammatory cytokines (Huether & McCane, 2012). This incites a widespread immune and inflammatory response, resulting in respiratory distress, abdominal cramping, swelling, and hives.
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- Mast cell, consequences. Anaphylaxis