Problem9andTakeHomeExam

Problem9andTakeHomeExam - 2. In the zoomed-in region of the...

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Problem 9 and take-home part of the final exam Chemistry 154A/254A: Quantum Chemistry Professor Song-I Han Teaching Assistant: Wang, Xiqing (Francis) Office: Chemistry 3223 Office: Chem 1126/ Dahlquist Lab (1 th floor) Office hours: Tue, Th 4-5 pm Office hours: Wed 1-2 pm and Fr 4-5pm Email: songi@chem.ucsb.edu Email: xwang@chem.ucsb.edu In the following pages we have a series of 2D spectra of a protein. These include a 2D NOESY, a zoomed-in region of the 2D NOESY, a 2D (N 15 -H 1 ) HSQC and a zoomed region of the HSQC spectrum. Questions: 1. Where is the H 2 O resonance in the 2D NOESY? Circle the region.
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Unformatted text preview: 2. In the zoomed-in region of the 2D (N 15-H 1 ) HSQC, there are eight sequential H-N resonances of amino acids amide protons highlighted by *. Each resonance comes from one amino acid residue in the protein. Assume that each of these resonances have been assigned to an amino acid residue (designated by letters) by means of specific NMR experiments. Now, use the zoomed-in 2D NOESY pattern to find the sequence of the eight amino acids . 2D 1 H-1 H NOESY 2D 1 H-15 N HSQC 2D 1 H-15 N HSQC zoomed-in region 2D 1 H-1 H NOESY zoomed-in region...
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This note was uploaded on 08/06/2008 for the course CHEM 154A taught by Professor Han during the Winter '08 term at UCSB.

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Problem9andTakeHomeExam - 2. In the zoomed-in region of the...

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