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Halpern_et_al_2006

Halpern_et_al_2006 - Strong Top-Down Control in Southern...

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DOI: 10.1126/science.1128613 , 1230 (2006); 312 Science et al. Benjamin S. Halpern, Kelp Forest Ecosystems Strong Top-Down Control in Southern California www.sciencemag.org (this information is current as of December 29, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/312/5777/1230 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/312/5777/1230/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/312/5777/1230#related-content http://www.sciencemag.org/cgi/content/full/312/5777/1230#otherarticles , 6 of which can be accessed for free: cites 21 articles This article 5 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/312/5777/1230#otherarticles 1 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/ecology Ecology : subject collections This article appears in the following http://www.sciencemag.org/about/permissions.dtl in whole or in part can be found at: this article permission to reproduce of this article or about obtaining reprints Information about obtaining registered trademark of AAAS. is a Science 2006 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on December 29, 2007 www.sciencemag.org Downloaded from
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pituitary remain to be determined. Further work on the functional role of AIP should prove informative in revealing key cellular processes involved in genesis of pituitary adenomas, in- cluding potential drug targets. It has not been previously realized that ge- netic predisposition to pituitary adenoma, in par- ticular the GH-oversecreting type, can account for a substantial proportion of cases. Our study not only reveals this aspect of the disease but also provides molecular tools for efficient identification of predisposed individuals. With- out preexisting risk awareness, the patients are typically diagnosed after years of delay, leading to substantial morbidity. Simple tools for efficient clinical follow-up of predisposed in- dividuals are available, underlining the impor- tance of our findings. Our results suggest that inherited tumor sus- ceptibility may be more common than previously thought. The identification of the PAP gene in- dicates that it is possible to identify the causative genetic defects in the low-penetrance conditions even in the absence of a strong family history.
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