Ans_to_questions - Answers to questions 1 In fatty acid...

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Answers to questions 1. In fatty acid biosynthesis a. How may elevated levels of ATP lead to activation of acetylCoA carboxylase? Elevated levels of ATP can inhibit isocitrate dehydrogenase which results in transport of citrate out of the mitochondria (tricarboxylic acid transporter) to the cytosol. There it can activate the carboxylase or be acted upon by citrate lyase to give acetylCoA which is the substrate for the carboxylase. Enzyme also needs ATP in order to catalyze synthesis of malonyl CoA. b. how does malonylCoA prevent “fruitless” cycling (ß-oxidation of fatty acids while they are being synthesized)? It inhibits transport of fatty acids into the mitochondria by inhibiting carnitine palmitoyl transferase 1. c. which carbon atoms would be labeled if [3- 14 C] malonyl CoA was used and the fatty acid produced was palmitate (C16:0)? None d. why can it be said that palmitic acid is synthesized from 8 molecules of acetylCoA/ CO 2 added to acetylCoA to form malonylCoA is the same CO 2 that is lost in formation of the ß-keto acyl intermediate.
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