lect_23 - LECTURE 23 MULTI-PULSE & MULTI-DIMENSIONAL NMR...

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LECTURE 23 MULTI-PULSE & MULTI-DIMENSIONAL NMR TECHNIQUES
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Important NMR Techniques for Structure Elucidation For Planer Structure DEPT (distortionless enhancement by polarization transfer) Identify protonated carbons ---- C n H m 1 H- 1 H COSY (Correlated Spectroscopy) Spin system ( 3 J vicinal coupling) TOCSY (Total Correlation Spectroscopy) Spin system (amino acid, protein) HMQC (Heteronuclear Multiple Quantum Coherence) HSQC (Heteronuclear Single Quantum Coherence) H-C 1 bond (J = 140 Hz) HMBC (Heteronuclear Multiple Bond Correlation)
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Important NMR Techniques for Structure Elucidation Interrelate J’S & δ ’S Rapidly make aciculate assignment Generate Working Structure For Relative Structure NOESY (Nuclear Overhauser Enhancement Spectroscopy) ROESY (Rotating Frame O. E. S.Y.) Through Space Coupling
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P170 SINGLE PULSE EXPERIMENTS
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SINGLE-PULSE VS. MULTI-PULSE PREP 90X DETECTION FID FT [t 2 ] [f 2 ] PREP 90X EVOLUTION MIXING DETECTION FID FT [t 1 ] [ τ ] [t 2 ] [f 2 ]
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P171 MULTI-PULSE EXPERIMENTS
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P171 MULTI-PULSE EXPERIMENTS THIS IS: INVERSION RECOVERY SEE ALSO “SPIN-ECHO” P174
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P177 CH 3 , CH CH 2
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This note was uploaded on 08/06/2008 for the course CHEM 124 taught by Professor Amagata during the Winter '08 term at UCSB.

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lect_23 - LECTURE 23 MULTI-PULSE & MULTI-DIMENSIONAL NMR...

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