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Microarray_design_analysis

Microarray_design_analysis - Microarray Design and Analysis...

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Unformatted text preview: Microarray Design and Analysis Genetics 875 November 20, 2007 Jeremy D. Glasner What is a Microarray? A collection of DNA sequences arrayed on a solid substrate usually with thousands of individual DNA spots Gene expression analysis Massively parallel biochemistry aimed at measuring RNA levels Why do gene expression analysis? • Predict new gene functions by expression patterns • Determine the effect of a drug on gene expression • Compare a mutant strain to wild-type • Identify an expression signature for a cancer type • Find the targets of a transcriptional regulator • Measure the half-lives of RNAs in the cell . . . Typical gene expression experiment TraSH: transposon site hybridization Sassetti CM, Boyd DH, Rubin EJ. Proc Natl Acad Sci U S A. 2001 98(22):12712-7 Genome wide localization of insertion mutations Rajashekara G, Glasner JD, Glover DA, Splitter GA. J Bacteriol. 2004 186(15):5040-51....
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Microarray_design_analysis - Microarray Design and Analysis...

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