Microarray_design_analysis

Microarray_design_analysis - Microarray Design and Analysis...

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Unformatted text preview: Microarray Design and Analysis Genetics 875 November 20, 2007 Jeremy D. Glasner What is a Microarray? A collection of DNA sequences arrayed on a solid substrate usually with thousands of individual DNA spots Gene expression analysis Massively parallel biochemistry aimed at measuring RNA levels Why do gene expression analysis? Predict new gene functions by expression patterns Determine the effect of a drug on gene expression Compare a mutant strain to wild-type Identify an expression signature for a cancer type Find the targets of a transcriptional regulator Measure the half-lives of RNAs in the cell . . . Typical gene expression experiment TraSH: transposon site hybridization Sassetti CM, Boyd DH, Rubin EJ. Proc Natl Acad Sci U S A. 2001 98(22):12712-7 Genome wide localization of insertion mutations Rajashekara G, Glasner JD, Glover DA, Splitter GA. J Bacteriol. 2004 186(15):5040-51....
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This note was uploaded on 08/08/2008 for the course GEN 875 taught by Professor Glasner during the Fall '07 term at Wisconsin.

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Microarray_design_analysis - Microarray Design and Analysis...

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