Glycosylation_PowerPoint

Glycosylation_PowerPoint - Carbohydrates: What Do They Do?...

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Carbohydrates: What Do They Do?
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Carbohydrates in Cell Recognition QuickTime D and a Photo - JPEG decompres or are ne ded to se this picture. Carbohydrates
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Carbohydrates in Disease White Blood Cells Inflammation Influenza Tumor antigens Lewis y Barrier to xenotransplantation Gal- α 1-3-Gal Conjugates
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Frontier: Understanding Carbohydrate Roles QuickTime ª and a Photo - JPEG decompres or are ne ded to se this picture. Carbohydrates Access to defined glycoconjugates is limited Individual protein– carbohydrate interactions are weak Lack compounds to probe biosynthetic pathways
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Oligosaccharides Are Complex 4 building blocks 1 site of attachment DNA Proteins 20 building blocks 1 site of attachment >8 building blocks 4 sites of attachment 2 different stereoisomers Carbohydrates
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Oligosaccharide Biosynthesis Is Not Template-Driven
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N- Glycosylation
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Glycosylation in the ER From: http://glycores.ncifcrf.gov/
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Glycan Diversity Generated in Golgi
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Structure of N-Glycan Imperiali, Curr. Opin. Chem. Biol. 1999 , 3 , 643
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Pharmacological Inhibitors of Glycosylation
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Glycosylation is Essential D. S. Peal, unpublished results
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Recruiting White Blood Cells
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This note was uploaded on 08/08/2008 for the course BIOCHEM 704 taught by Professor Kiessling during the Spring '08 term at Wisconsin.

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Glycosylation_PowerPoint - Carbohydrates: What Do They Do?...

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