NURS 6521N-30: Advanced Pharmacology WEEK 9 INITIAL POST Thalassemia Thalassemia syndromes are a heterogeneous group of inherited disorders of hemoglobin synthesis. They are a type of hemoglobinopathy and are disorders of decreased globin chain production (Arcangelo and Peterson, 2013). Hemoglobin is made of two proteins alpha globin and beta globin. Thalassemia occurs when there is a defect in a gene that helps control production of one of these proteins. Symptoms of thalassemia include bone deformities in the face, fatigue, growth failure, shortness of breath, and jaundice (CDC, 2016). There are two main types of thalassemia; alpha thalassemia, which occurs when a gene or genes related to the alpha globin protein are missing, changed, or mutated and beta thalassemia, which occurs when similar gene defects affect production of the beta globin protein (CDC, 2016). Each type has many different subtypes that are classified according to the form of the illness. Both alpha and beta thalassemia include the following two forms; thalassemia major and thalassemia minor (Arcangelo and Peterson, 2013). Thalassemia major you must inherit the gene defect from both parents. Thalassemia minor occurs from a faulty gene from only one parent.
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- Fall '13
- Hemoglobin, thalassemia, thalassemia trait