TOPIC 8a - TOPIC 8a b THE CYTOSKELETON INTERMEDIATE FILAMENTS(Slides 1 to 7 ACTIN FILAMENTS(Slides 8 on Ancillary Slides for Topic 8b The

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THE CYTOSKELETON: INTERMEDIATE FILAMENTS (Slides 1 to 7) ACTIN FILAMENTS (Slides 8 on) Ancillary Slides for Topic 8b The cytoskeleton consists of a special system of protein filaments that extend throughout the cell The cytoskeleton is responsible for cell shape and cell movements from the movement of transport and secretory vesicles, to amoeboid and ciliary movements to the movement of muscles The cytoskeleton also plays a pivotal role in the connections between cells and hence in the structure of tissues The principal cytoskeletal elements are intermediate filaments (10 nm), microfilaments (actin filaments)(5 to 9 nm) and microtubules (25 nm) Actin filaments (also called microfilaments) assemble by the head-to-tail polymerization of G-actin monomers into F-actin. Actin filaments are associated with a variety of accessory proteins Actin filaments are closely associated with the plasma membrane and are responsible for much of a cell's shape and movements We are commencing four lectures on various aspects of the cytoskeleton. We will start with a description of (1) the cytoskeleton in general and then (2) intermediate filaments and (3) microfilaments (actin filaments). Study pp. 425 - 426 first; then pp. 446 - 450 Intermediate Filaments, and finally 437-445. know this material very well. Intermediate filaments are polymers of more than fifty different
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This note was uploaded on 08/06/2008 for the course BIO 1140 taught by Professor Fenwick during the Winter '07 term at University of Ottawa.

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TOPIC 8a - TOPIC 8a b THE CYTOSKELETON INTERMEDIATE FILAMENTS(Slides 1 to 7 ACTIN FILAMENTS(Slides 8 on Ancillary Slides for Topic 8b The

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