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Unformatted text preview: TOPIC 11: EXTRACELLULAR MATRIX FOUR FUNDAMENTAL PROPOSITIONS The extracellular matrix of animals consists of two principal components; a gel-like 'ground substance' which resists compression forces and fibrous proteins, principally collagen and elastin, which give it tensile strength. Plant and bacterial cell walls are functionally analogous to the extracellular matrix (glycocalyx) of animal cells. Cellulose fibers in the plant cell wall confer tensile strength; other wall components prevent compression. Chemically, the bacterial cell wall is a single large molecule. 97-98, 482 - 492 proteoglycans are molecules consisting of glycosaminoglycans (GAGs, which are very complex carbohydrate molecules containing an amino sugar, e.g. N-acetylglucosamine and N-acetylgalactosamine) that are covalently bonded to proteins that get highly hydrated to make up the bulk of the gel-like 'ground substance' in the extracellular matrix. A characteristic of these molecules is that they have a very large proportion of carbohydrate (up to 96% by matrix....
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This note was uploaded on 08/06/2008 for the course BIO 1140 taught by Professor Fenwick during the Winter '07 term at University of Ottawa.
- Winter '07