TOPIC 16 - TOPIC 16: TRANSLATION mRNA sequences are decoded...

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TOPIC 16: TRANSLATION mRNA sequences are decoded in sets of three nucleotides tRNA matches specific amino acids to codons on the mRNA proteins are made on polyribsomes where the RNA message is actually decoded Translation is the process that interprets the order of nucleotides in mRNA and generates the linear sequence of amino acids in proteins. This is one of the most conserved features, one of the most energetically costly (80% of metabolism in rapidly growing bacteria) and certain one of the most complex involving the coordinated action of no less than 100 proteins and RNAs. Study pp. 684 -698 and pay particular attention to The stages of Translation . There is a lot of detail in here so you will have to take your lead from what is covered in lectures. We will concentrate on the situation in eukaryotes! TRANSLATION: The assembly or synthesis of proteins. Unlike replication and transcription, translation takes place outside of the nucleus, in the cytoplasm (i.e., the various RNA species, all produced in the nucleus, must move through the nuclear envelope), and includes initiation, elongation and termination. Initiation: Requires a small ribosomal subunit (40s) , an initiation tRNA called tRNA Met i (with a 5'-CAU-3' anticodon), and the mRNA initiation (start) codon (5'-AUG-3' ), all of which form the pre-initiation complex. When all of these parts are in
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TOPIC 16 - TOPIC 16: TRANSLATION mRNA sequences are decoded...

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